ASPO Abstracts
Comprehension, satisfaction, and responses to MC1R genetic test results in a diverse population of primary care patients
Category: Behavioral Science & Health Communication, Molecular Epidemiology & Environment
Conference Year: 2018
Abstract Body:
Background: Common germline variants in the melanocortin-1 receptor (MC1R) gene confer a two- to three-fold increase in melanoma risk in the general population. Understanding patients’ responses to genetic test feedback will help shape the public health translation potential of melanoma genetic testing, as it may inform precision prevention strategies for melanoma. Study Aims: As part of a randomized controlled trial examining interest, uptake, and utility of MC1R genetic testing in Albuquerque, New Mexico primary care settings, we examined the following responses two weeks after test results receipt: 1) Comprehension and recall of results; 2) Satisfaction with testing; 3) Emotional reactions to results; 4) Intended behavior changes related to testing; and 5) Family communication regarding results. Methods: Participants who requested and followed through with testing by returning the saliva test kit (n=145, aged 23-79, 10% ‰¤ high school education) received a results report indicating either average or higher risk for developing melanoma. The Risk Feedback Comprehension Assessment, a follow-up survey with open-and close-ended questions, was conducted via telephone or email two weeks after results were received. Results: Of the 145 participants who received results, 57 (39%) had average risk results, and 88 (61%) had higher risk results. Most (81%) participants correctly recalled their results. Overall, participants found their results to be believable (M=6.43 out of 7, SD=1.37) and clear (M=6.22 out of 7, SD=1.19). They had low levels of adverse emotional reactions, such as nervousness (M=1.96 out of 7, SD=1.41) and test regret (M=1.50 out of 7, SD=1.05), regardless of average or higher risk results. Those with higher melanoma risk had greater determination to change sun protection compared to those with average risk (M=4.94 vs. M=3.68, respectively, p=<.001). Most (64%) had discussed their results with family.
Keywords: genetic testing; primary care; melanoma prevention; skin cancer risk; genetic risk communication