ASPO Abstracts
Inflammatory potential of diet, inflammation-related lifestyle factors and risk of pancreatic cancer: results from the NIH-AARP Diet and Health Study
Category: Inflammation & Cancer, Lifestyles Behavior, Energy Balance & Chemoprevention
Conference Year: 2018
Abstract Body:
Background: Inflammation-related lifestyle factors such as smoking and obesity may act synergistically with inflammatory potential of diet, to affect pancreatic cancer risk. We used data from the NIH-AARP Diet and Health Study to prospectively examine the association between dietary inflammatory potential and pancreatic cancer and examine the effect modification by important inflammation-related lifestyle factors including body mass index, cigarette smoking, diabetes history, alcohol drinking and use of non-steroidal anti-inflammatory drugs. Methods: The analytical cohort consisted of 533,286 participants (314,162 men and 219,124 women) aged between 50 to 71 years at baseline. Energy-adjusted dietary inflammatory index (E-DII) scores were computed based on food and supplement intake. The outcome was defined as incident primary adenocarcinoma of the exocrine pancreas. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) with participants in the lowest E-DII quintile (most anti-inflammatory scores) as referent. Effect modification was examined by adding a cross-product of each effect modifier as a categorical variable with E-DII quintile in the multivariable-adjusted model. Results: After a median 13.4 years of follow-up, a total of 2,824 primary pancreatic cancer cases occurred. After controlling for confounders, there was no significant association between E-DII scores and pancreatic cancer risk among both men (HRQ5vsQ1=1.00, 95% CI=0.86-1.17, P-trend=0.83) and women (HRQ5vsQ1=1.00, 95% CI=0.83-1.22, P-trend=0.82). Inflammatory potential of diet was not associated with pancreatic cancer by cancer stage or grade. The E-DII and pancreatic cancer association was not modified by any of the inflammation-related lifestyle factors. Conclusion: Our study did not support an association between inflammatory potential of diet and pancreatic cancer. No significant effect modification between the E-DII and other inflammation-related lifestyle factors on pancreatic cancer etiology were detected.
Keywords: Inflammation, dietary inflammatory index, lifestyle factors, pancreatic cancer, cohort study