ASPO Abstracts
Trends in Endometrial Cancer Incidence by Race/Ethnicity and Age
Category: Cancer Health Disparities
Conference Year: 2023
Abstract Body:
PURPOSE: This study used an intersectional approach to examine trends in endometrial cancer (EC) incidence in the United States by race/ethnicity and age. METHODS: Data on EC incidence in the United States between 2000-2019 were from the SEER 17 registries. SEER*Stat software was used to calculate age-adjusted incidence rates by race/ethnicity and age. Rates were adjusted to the 2000 US Standard population. Race/ethnicity was classified into non-Hispanic whites (white), non- Hispanic Blacks (Black), non-Hispanic American Indian/Alaskan Natives (AI/AN), non-Hispanic Asian or Pacific Islanders (API), and Hispanic/Latinos (Latinos). Age of diagnosis was dichotomized into less than 45 years old and 45 years and older. Joinpoint Regression Software was used to calculate annual percent change (APC) and conduct trend analyses of age-adjusted EC incidence by race/ethnicity and age. RESULTS: Between 2010-2019, there were a total of 215,503 EC cases. During this period, all racial/ethnic groups observed a statistically significant APC in EC incidence. However, AI/ANs observed the highest APC (2.84), followed by Latinos (2.68), Blacks (2.66), APIs (2.60), and whites (0.84). Of important concern, women of all race/ethnicities diagnosed below 45 years old had statistically significant increases in EC incidence, with the greatest APC observed among AI/ANs (4.49) and Latinos (4.29), followed by Blacks (3.22), APIs (2.80), and whites (1.75). Trends for women ages 45 years and older were also statistically significant, with the greatest APC observed among Blacks (2.62), followed by APIs (2.55), AI/ANs (2.49), Latinos (2.45), and whites (0.77). CONCLUSIONS: Historically, EC has largely affected non-Hispanic white and postmenopausal women. However, our results indicate that in the early 21st century EC is impacting more racial/ethnic minority women at younger ages, perhaps due to increases in certain risk factors. Given that there is no screening for EC, careful clinical attention needs to be given to younger racial/ethnic minority women to ensure early diagnosis and treatment. Further, our results show that racial/ethnic minority women represent an important segment of the survivorship population in which future research and interventions should be directed towards.
Keywords: Endometrial Cancer; Incidence; Racial/Ethnic Disparities