ASPO Abstracts
Aspirin use and occurrence of colorectal adenoma in Black American women
Category: Cancer Health Disparities
Conference Year: 2023
Abstract Body:
Purpose: To assess the association between aspirin use and colorectal adenoma among Black women, who are disproportionately burdened by the disease compared to their White counterparts. Methods: The Black Women's Health Study is a prospective cohort of self-identified Black American women established in 1995. Participants reported regular aspirin use on baseline and follow-up questionnaires. Beginning in 1999, participants reported undergoing a colonoscopy or sigmoidoscopy, the only procedures through which colorectal adenomas can be diagnosed. Multivariable logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for associations between aspirin use and colorectal adenoma among 34,397 women who reported at least one colonoscopy or sigmoidoscopy. Results: From 1997 through 2018, 1,913 women were diagnosed with an adenoma. Compared to non-aspirin users, regular users had a 14% (OR=0.86, 95% CI 0.78-0.95) lower odds of adenoma. The odds of adenoma decreased with increasing duration of aspirin use (≥10 years: OR=0.80, 95% CI 0.66-0.96, p- trend=0.01). Initiating aspirin at a younger age was associated with a reduced odds of colorectal adenoma (age <40 years at initiation: OR=0.69, 95% CI 0.55- 0.86). Conclusions: Regular aspirin use was associated with a decreased odds of colorectal adenoma in this study of Black women. These findings support the chemopreventive impact of aspirin on colorectal neoplasia and suggest that aspirin may be a useful prevention strategy among U.S. Black women.
Keywords: Aspirin; Colorectal adenoma; Black Women