ASPO Abstracts
Post-Diagnostic Alcohol Consumption and Risk of Prostate Cancer Progression
Category: Lifestyles Behavior, Energy Balance & Chemoprevention
Conference Year: 2023
Abstract Body:
PURPOSE OF THE STUDY: The association between post-diagnostic alcohol consumption and the risk of prostate cancer progression remains unclear. We prospectively examined this association in a large cohort of men with prostate cancer. METHODS: Men diagnosed with prostate cancer actively participating in the Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) cohort study were invited to complete a validated Food Frequency Questionnaire (FFQ) (up to twice between 2003-2005 and once between 2015-2017). 1895 patients completed the FFQ with valid calories at least once prior to cancer progression. Only 443 completed more than one survey, so we used data from each patient's first available FFQ only for this study. Our primary exposures were total alcohol (g/d) and types of alcohol (red and white wine, beer, liquor; drinks/day). The primary outcome was a composite outcome that included biochemical recurrence, need for secondary treatment, bone metastases, or death attributed to prostate cancer assessed through urologist report with medical record and death certificate confirmation. We used multivariable Cox proportional hazards regression models to calculate hazard ratios (HR) and 95% confidence intervals (CI) for the associations between alcohol intake and the risk of prostate cancer progression, adjusting for time from diagnosis to the survey, study site, Gleason score, diagnostic PSA, age, primary treatment, daily calories and walking pace. RESULTS: Among 1,795 men (162 events, median 6.69y follow-up), we found no statistically significant association between total alcohol and risk of prostate cancer progression. However, red wine consumption was found to be associated with lower risk of prostate cancer progression, with an adjusted HR of 0.34 (95%CI 0.18, 0.67; p=0.02) for prostate cancer progression among patients drinking >=5 vs. 0 glasses/week of red wine (p-trend=0.0007). No other type of alcohol was found to be associated with the risk of prostate cancer progression. CONCLUSION: While we found no evidence for an association between post-diagnostic consumption of alcohol in general and risk of prostate cancer progression, consumption of at least 5 glasses of red wine per week may be associated with lower risk of prostate cancer progression.
Keywords: prostate cancer survivorship, cancer recurrence, wine