ASPO Abstracts
Dietary Patterns and Clinical Characteristics of BEWELL Study Participants: A Cohort at High-Risk for Lung Cancer (NCT04267874)
Category: Lifestyles Behavior, Energy Balance & Chemoprevention
Conference Year: 2022
Abstract Body:
Background: The BEWELL Study is a randomized, cross-over trial examining feasibility and impact of a novel black raspberry (BRB) nectar on microbiome and immune function in a high-risk cohort for lung cancer. This report describes demographic characteristics, compliance, toxicity, and diet/exercise patterns in this cohort.Methods: Eligible individuals aged 55-77 with 30+ pack-year smoking histories were recruited from the OSU Lung Cancer Clinic and social media. Participants consumed BRB nectar (berries-to-powder converted to nectar by OSU Food Science Dept) and a texture/taste-matched placebo during two 4-week periods with a 2-week washout. Participants completed medical history, food frequency, BRB compliance, and physical activity (IPAQ) surveys. Blood/urine/stool specimens were also submitted.Results: Of 337 individuals contacted, 96 consented, 62 initiated the study and 33 completed the 10-week study. Of these, 73% were former smokers (24/33), with mean age of 65 years (range 58-76 years). Overall adherence (% nectar/placebo consumed) was 97%. Mean BMI was 29.7 and 57% had 'minimally active' IPAQ scores. The mean Healthy Eating Index (HEI-2015) score was 59 (range=39-74). Females exhibited significantly higher HEI scores than males (63 and 55, respectively; t=2.83, p<0.01), with significantly higher fruit consumption (t=2.70, p=0.012). The empirical dietary inflammatory pattern (EDIP; mean=1.6, range=-1.6-2.7), which assesses the inflammatory potential of the diet showed significantly lower inflammatory diets for females vs males (t=-2.30; p=0.03). No significant differences were found for diet quality indices by smoking status, BMI or age. Conclusions: Participants showed high compliance and low toxicity to the BRB intervention, confirming the feasibility of conducting this intervention in a high-risk smoking population. They were mostly overweight, had unhealthy diets and low activity levels (compared to national estimates). The mean HEI was similar to the national average, however, with females exhibiting significantly healthier and less inflammatory dietary patterns, and higher fruit consumption, which has also been reported nationally. Next steps will be to assess potential associations of these results with plasma cytokine and microbiome data.
Keywords: lung cancer, chemoprevention