ASPO Abstracts
Effect of Comprehensive Lifestyle Modification Intervention on Health-Related Quality of Life in Prostate Cancer Survivors on Androgen Deprivation Therapy
Category: Survivorship & Health Outcomes/Comparative Effectiveness Research
Conference Year: 2022
Abstract Body:
Purpose: To determine the effect of the Comprehensive Lifestyle Improvement Program for Prostate Cancer (CLIPP) on Health-Related Quality of Life (HRQoL), in men on androgen deprivation therapy (ADT) for prostate cancer.Methods: A single-arm, open label, clinical trial was conducted by recruiting 31 men exposed to ADT within the last five years. A multi-component lifestyle modification intervention (based on a modified Diabetes Prevention Program protocol), consisting of a low-fat diet with aerobic physical activity, was delivered weekly for 16 weeks by a trained health coach. Post-intervention, participants were followed for eight additional weeks to complete a total follow-up period of 24 weeks. The Patient Reported Outcomes Measurement Information System (PROMIS) questionnaire (scored domains: physical and mental health) and the Expanded Prostate Cancer Index Composite (EPIC-26) questionnaire (scored domains: urinary incontinence, urinary irritation, bowel, sexual and hormonal related well-beings) were used to assess overall and disease specific quality of life at baseline, 12, and 24 weeks: Mixed effects regression models (adjusted for age, stage of disease, and duration of ADT) were implemented to determine the changes in HRQoL over time.Results: Statistically significant improvements in self-reported HRQoL were noted in physical health (p=0.005), urinary irritation (p=0.01), bowel (p=0.001) and hormonal symptoms (p=0.003) domains. Minimally important differences (indicating clinical relevance) were exceeded for the urinary irritation, bowel, and hormonal domains. Conclusion: The CLIPP intervention demonstrates statistically significant and clinically meaningful improvements in overall and prostate cancer-specific quality of life. Lifestyle modification may be beneficial in mitigating ADT associated adverse effects and improving HRQoL of men on ADT for prostate cancer.
Keywords: Prostate Cancer, Androgen Deprivation Therapy, Lifestyle Modification