ASPO Abstracts
Rice bran and navy bean intake alters the amino acid profile and healthy eating index of adults at risk for colon cancer
Category: Lifestyles Behavior, Energy Balance & Chemoprevention
Conference Year: 2022
Abstract Body:
Purpose of the Study: Beans/Bran Enriching Nutritional Eating For Intestinal health & Cancer Including Activity for Longevity (BENEFICIAL) is a pilot trial to examine whether increased fiber intake with rice bran and navy beans or a fiber control supplement, while accounting for physical activity levels, results in changes to host metabolism in adults at high risk for colorectal cancer.Methods: Twenty adults with colonic polyps removed in the last 3 years and diagnosed with stage 0-1 colon cancer were enrolled and randomized according to body mass index and sex. Participants were allocated to placebo (fibersol-2 (10 g) per day) or intervention (rice bran 30g + navy bean 30g) for 3-months. Fiber intake was measured through study foods and using Nutritionist Pro via the analysis of 3-day food records. The ASA 24 nutritional composition database was used to generate healthy eating index (HEI) and food group composite scores. Non-targeted metabolomics was performed on blood, urine, and stool to identify dietary biomarkers of rice bran/navy beans, and to measure impacts on host and gut metabolic pathways of importance to reducing colonic inflammation and cancer risk. Physical activity was measured using ActivePal accelerometers. All participants received a physical activity education session aligned with the American Cancer Society.Results: Increased daily fiber intake through consumption of study foods and powders for all participants was associated with improved HEI scores. Participants consuming rice bran/navy bean intervention showed increased plasma concentrations in pipecolate at 6 weeks 2.00-fold and 12 weeks 4.15-fold and 4-methoxyphenol sulfate 14.48-fold at 6 weeks and 3.07-fold at 12 weeks when compared to control. Urine amino acid metabolite profiles revealed N-methylleucine 12.55-fold and 24.29-fold, and S-methylcysteine 3.33-fold increase at 12 weeks. Conclusion: This study demonstrated changes to amino acid metabolic pathways and are affordable means of adhering to national guidelines for prevention in a high-risk population.
Keywords: Rice Bran, Navy bean, Metabolomics, Amino Acids, Colorectal Cancer