ASPO Abstracts

Beans/Bran Enriching Nutritional Eating For Intestinal health & Cancer Including Activity for Longevity

Authors: Baxter BA, Beale M, Ford H, Haberecht H, Hibbs-Ships S, Leach HJ, & Ryan EP

Category: Lifestyles Behavior, Energy Balance & Chemoprevention
Conference Year: 2020

Abstract Body:
Purpose of the study: A pilot, randomized controlled trial was conducted to evaluate increased fiber intake using rice bran plus cooked navy bean powders versus a corn soluble fiber supplement, and while accounting for physical activity levels to reduce colorectal cancer risk. Methods: We enrolled 20 high-risk adults with colon polyps removed in the last 3 years. Participants were allocated to placebo (fibersol-2) or intervention (rice bran 30g + navy bean 30g) for 3-months. Nutritionist Pro was used to analyze 3-day food records and ASA 24 was applied to generate healthy eating index (HEI). Metabolomics of blood, urine, and stool was utilized to measure biomarkers of dietary intake and investigate impacts of fiber sources on lipid, amino acid and carbohydrate metabolism. Physical activity was measured using activePal. All participants received a physical activity education session aligned with the ACS guidelines. Results: All participants improved total HEI scores. All participants exceeded physical activity guidelines for moderate to vigorous activity (min/week), however average steps per day were not met (steps/day). Participants’ consuming rice/navy bean intervention showed changes in stool short chain fatty acids and primary and secondary bile acids. Significant decrease in serum triglycerides, and elevated HDL were observed in the intervention group after 3 months when compared to the controls. Plasma metabolite profiling revealed a significant (p<0.05) fold difference of pipecolate, S-methylcysteine, S-methylcysteine sulfoxide, lactate, and 9, 10- DiHOME. Urine metabolites with significant (p<0.05) fold differences were 4-methoxyphenol sulfate, N- methylleucine, and S-methylcysteine. Interindividual variation in gut microbial taxa between groups showed participants cluster more closely to themselves than by time. Conclusion: This study demonstrates a practical and affordable means of adhering to national guidelines and measuring metabolic responses involving the microbiome for colorectal cancer control and prevention.

Keywords: Colon cancer Physical activity Healthy eating index Fiber