ASPO Abstracts
Associations between sedentary behavior, blood lipids, and glucose among individuals at high risk for colorectal cancer
Category: Lifestyles Behavior, Energy Balance & Chemoprevention
Conference Year: 2020
Abstract Body:
Purpose: Dyslipidemia and hyperglycemia are associated with increased risk of colorectal cancer (CRC), the
third leading cancer diagnosis in the United States. Moderate-vigorous physical activity (MVPA) can improve
components of dyslipidemia and hyperglycemia, but the role of sedentary behavior (SB), independent of PA, is
not as clear. This study examined cross-sectional associations between components of SB, blood lipids, and
glucose among individuals at high risk for CRC.
Methods: Adults (≥18 years) with ≥ 1 adenomatous polyps removed within the past 3 years, were monitored
continuously for 7 consecutive days using an activPAL accelerometer to measure SB and PA. Fasted blood
samples were analyzed for total cholesterol, triglycerides, high density lipoprotein (HDL), low density
lipoprotein (LDL), and glucose using standard procedures. Pearson correlations explored associations
between a series of lipids and glucose with minutes in SB >30 or >60, and number of SB bouts >30 or >60
minutes. Variables with at least moderate associations (r>.3) were included in hierarchical regression models
along with waist circumference (WC) and MVPA to predict blood lipid and glucose outcomes.
Results: Participants (N=23) were M=58.9 ± 9.0 years old (52.2% female) spending on average 71.22 ± 23.02
min/day in MVPA and 560.03 ± 97.31 min/day sedentary. Time spent in SB bouts >30 min (r= .50) and >60 min
(r= .56), number of SB bouts > 30 min (r=0.36) and >60 min (r=.59) were associated with glucose. SB bouts
lasting >30 min was associated with total cholesterol (r= .35). The regression model for number of SB bouts
lasting >60 min, WC and MVPA was significant [F(3, 18)=3.17, p=.05, R2=.35], and accounted for an additional
34.5% of the variance [=7.56, SE=2.47, t(3)=3.07, p=.007]. Regression models for the other predictors were
not significant.
Conclusion: Findings from this study suggest that, in terms of glucose control, those at high risk for CRC may
benefit from reducing long duration bouts of SB in addition to participating in MVPA. Additional studies are
needed to examine the effects of changes in SB on biomarkers for CRC control and prevention.
Keywords: Colorectal Cancer, Sedentary Behavior, Glucose