ASPO Abstracts
Physical activity, sitting time, and risk of myeloid neoplasms
Category: Lifestyles Behavior, Energy Balance & Chemoprevention
Conference Year: 2019
Abstract Body:
PURPOSE: To explore the associations of moderate-to-vigorous physical activity (MVPA) and sitting time with the risk of myeloid neoplasms (MN), and MN subtypes myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML).METHODS: Among the 109,010 Cancer Prevention Study-II participants (mean age 68.8, SD 5.9 years in 1999) included in this analysis, 409 were diagnosed with a MN (n=155 AML, n=154 MDS) over 14 years of follow-up (1999-2013). Cox proportional hazards regression was used to calculate multivariable hazard ratios (HR) and 95% confidence intervals (CI) to estimate associations of MVPA (metabolic equivalent [MET]-hours/week) and sitting time (hours/day) with risk of all MN, MDS, and AML. RESULTS: Compared to insufficient MVPA (>0-<7.5 MET-hours/week), the HR (95% CI) for 7.5-<15 MET-hours/week MVPA and risk of all MN was 0.74 (95% CI, 0.56-0.98) and for 15-<22.5 MET-hours/week was 0.75 (0.53-1.06); however, there was no association among the most active participants (22.5+ MET-hours/week, HR = 0.92, 0.72-1.18). Similarly, for MDS, the HR for 7.5-<15 MET-hours/week MVPA and 15-<22.5 MET-hours/week (vs. >0-<7.5 MET-hours/week) were 0.55 (0.34-0.89) and 0.50 (0.26-0.95), respectively, and there was no association among the most active (22.5+ MET-hours/week, HR = 0.89, 0.61-1.30). MVPA was not associated with risk of AML. Sitting time was not associated with risk of all MN, MDS, or AML.CONCLUSIONS: This study suggests there may be a non-linear inverse association between MVPA and risk of MN. This relationship seems to be driven largely by the association of MVPA with a risk of the MDS subtype. Larger studies are needed to understand the dose-repose relationships, particularly for MN subtypes.
Keywords: exercise, sedentary, myeloid leukemia