ASPO Abstracts
Association between bone resorption biomarkers and body fat percent in overweight and obese breast cancer survivors
Category: Survivorship & Health Outcomes/Comparative Effectiveness Research
Conference Year: 2019
Abstract Body:
INTRODUCTION: Obesity-induced reductions in osteocalcin and bone-specific alkaline phosphatase (BSAP) are associated with bone resorption and degradation. Therefore, obese individuals with high body fat percentage may experience reductions in bone mineral density (BMD) and increased risk of fracture. Breast cancer survivors often experience increases in body fat percentage as a result of cancer-related treatments, and hence may be more susceptible to adverse changes in bone resorption than non-cancer populations. PURPOSE: The purpose of this study was to determine whether body fat percent was associated with the biomarkers of bone resorption, osteocalcin, and BSAP, in overweight and obese breast cancer survivors. METHODS: One hundred sedentary, overweight or obese breast cancer survivors (BMI ≥ 25 kg/m2; Stages I-III) were included in this study. Body fat percent was obtained from a whole-body scan using the Dual Energy X-Ray Absorptiometry (DEXA; Lunar GE iDXA, Fairfield, Connecticut). Osteocalcin and BSAP were measured using enzyme-linked immunosorbent assays from fasting blood samples. Pearson’s correlations were used to assess the association between body fat percent and the two bone biomarkers. RESULTS: On average, the women were 53.510.4 years old, postmenopausal (60%), Hispanic (55%) with a BMI of 33.55.5 kg/m2. Mean values for body fat percent and biomarkers of bone resorption were as follows: body fat percent 36.9%4.9, osteocalcin 12.23.25 ng/ml, and BSAP 16.154.5 ng/ml. There were strong correlations between body fat percent and osteocalcin (r=0.723; p<0.001) and between body fat percent and BSAP (r=0.819; p<0.001).CONCLUSION: Body fat percent was associated with biomarkers of bone resorption in overweight and obese breast cancer survivors. Therefore, high body fat percent may further contribute to poor bone health caused by cancer-related treatments. Targeting body fat with lifestyle interventions may be of vital importance to consider during cancer survivorship, in order to improve bone health among overweight and obese BCS.
Keywords: breast cancer osteoporosisobesitybone health