ASPO Abstracts
Alcohol consumption and all-cause mortality for women diagnosed with breast cancer in the prospective family study cohort (ProF-SC)
Category: Survivorship & Health Outcomes/Comparative Effectiveness Research
Conference Year: 2019
Abstract Body:
Purpose: To examine the association of pre-diagnostic alcohol consumption with all-cause mortality after breast cancer (BC) diagnosis using data from the Prospective Family Study Cohort (ProF-SC).Methods: We studied 4,575 women diagnosed with a first primary BC and enrolled in ProF-SC within 2 years after diagnosis. We evaluated the association between pre-diagnostic alcohol consumption and all-cause mortality using multivariable Cox Proportional Hazard models, adjusting for age at BC diagnosis, study site, race/ethnicity, education, BMI, age at first pregnancy, parity, breastfeeding, oral contraceptive use, hormone therapy use, menopausal status, estrogen receptor status, tumor stage, and cigarette smoking. We defined alcohol consumption as the average number of total alcoholic drinks per week, categorized as < 7 and ≥ 7 drinks/week. We defined one drink as a 12 oz. serving of beer, one medium glass of wine, or one shot of liquor. We assessed multiplicative interaction by absolute predicted 1-year BC familial risk estimated from pedigree models. Results: During 53,759 person years of follow-up (median:12.5, maximum:21.7 years), we observed 1140 deaths in women with an average age of first BC diagnosis of 47.8 years. Overall, compared with non-regular drinkers we did not find any association between alcohol consumption and all-cause mortality. When stratified by age at BC diagnosis, we found a 27% increased mortality risk associated with regular alcohol consumption (≥ 7 drinks per week) for women aged < 50 years at diagnosis (Hazard Ratio (HR) 1.27, 95% CI: 1.01, 1.61), but no association for older women. Predicted 1-year BC familial risk modified the association between regular alcohol consumption (≥7 drinks per week) and overall mortality (p-interaction: 0.04), such that women at the 95th percentile of absolute predicted 1-year BC familial risk had a 59% increased risk (HR: 1.59, 95% CI: 1.13, 2.23), while women at 5th percentile were not at increased risk (HR: 1.04, 95% CI: 0.94, 1.35). Conclusions: Pre-diagnostic alcohol consumption is not associated with all-cause mortality for women overall although there might be an association for women diagnosed before age 50 and for women with a higher absolute BC familial risk who regularly consume alcohol.
Keywords: prospective family study cohort, all-cause mortality, lifestyle modification, breast cancer survivorship