ASPO Abstracts
HPV Vaccination Rates Among Childhood Cancer Survivors in South Texas
Category: Survivorship & Health Outcomes/Comparative Effectiveness Research
Conference Year: 2019
Abstract Body:
Purpose of the study: Compared to the U.S. general population, childhood cancer survivors(CCS) experience significantly higher rates of HPV-related malignancies, yet are not currentlytargeted in population-based HPV vaccine initiatives. This study aims to evaluate HPV vaccinationrates among CCS in South Texas. Methods: Medical records of CCS at the South Texas Children’s Cancer and Blood DisordersCenter in San Antonio, Texas were retrospectively reviewed to identify all patients potentiallyeligible to receive the HPV vaccine (age 11-26 during 2006-2016). Of 210 cancer survivors, 156 wereeligible. Review of vaccine records through Texas ImmTrac vaccine registry and electronic clinicalrecords verified HPV vaccination status. Demographic and clinical variables collected includeddate of birth, gender, race/ethnicity, cancer diagnosis, and cancer treatment.Results: Among 156 vaccine-eligible patients, 21 (13.5%) received any vaccine with 9 (5.7%) completing the 3-dose series. Of the 84 females, 16 (19%) initiated and 9 (10.7%)completed the series. However among 72 males, only 5 (6.9%) initiated with no completions. Thepopulation of CCS treated in South Texas is largely Hispanic (76%). Among the 119 Hispanic CCS, only 17 (14%) initiated and 7 (6%) completed the series. Sixteen patients (10.3%) received radiation torisk areas for HPV-related disease: abdomen, pelvis, whole spine or whole body. However, only 2 (13%) of these initiated the series and none completed. Twelve (7.7%) CCS received prior stem cell transplant, but only 1 initiated and completed the series. Conclusions: HPV vaccination rates among pediatric survivors in South Texas are lower than demonstrated in the general population for Bexar county, Texas, and nationally. Given theincreased susceptibility to second HPV-related cancers, particularly in those who received abdominalor pelvis radiation, SCT, or remain immunocompromised, this study demonstrates need for strengthened pediatric survivor HPV vaccination and identifies an at-risk gap population.
Keywords: HPV Vaccine, Survivorship,Hispanic Survivors