ASPO Abstracts
Chemotherapy induced peripheral neuropathy and physical activity in women who have recently completed treatment for ovarian cancer
Category: Lifestyles Behavior, Energy Balance & Chemoprevention
Conference Year: 2019
Abstract Body:
Purpose Chemotherapy-induced peripheral neuropathy (CIPN) is a commonly reported symptom in ovarian cancer survivors which can increase the risk for falls, reduce health-related quality of life and may potentially act as a barrier to physical activity. The purpose of this study was to determine the relationship between the presence of CIPN and physical activity levels in post-treatment ovarian cancer survivors enrolled in the Lifestyle Intervention for oVarian Cancer Enhanced Survival (LIVES) study, GOG/NRG 0225.MethodsThe LIVES study is an NRG/NCORP sponsored trial, evaluating whether ovarian cancer survivors randomized to a telephone-based diet and physical activity intervention versus an attention control for 24 months will have longer progression-free survival. Severity of CIPN (0-10) and self-reported physical activity (total and recreational MET hr/week) were collected at baseline tusing the MD Anderson Symptom Inventory for Ovarian Cancer and the Arizona Physical Activity Questionnaire. Multiple linear regression models adjusted for age, body mass index (BMI), total number of symptoms, co-morbidities, education, marital status, smoking status, race and ethnicity were used to evaluate the relationships between CIPN and total as well as recreational physical activity. Results Complete data were available from 380 women participating in the LIVES trial. Average age and BMI of the women was 59.3 ± 9.5 years and 27.7 ± 6.1 kg/m2, respectively. Eighty percent of ovarian cancer survivors reported the presence of CIPN at study enrollment with an average severity score of 4.8±2.5. Women reported an average of 263.3 ± 36.3 total MET hours/week and an average of 15.32 ± 17.7 recreational MET hours/week. Both total MET hr/week (-0.02%; 95%CI: -0.48, 0.45) and recreational MET hr/ week (1.1%, 95%CI: -3.4, 5.6) were not significantly associated with CIPN. Conclusions These data suggest CIPN is not associated with physical activity in women completing treatment for ovarian cancer. Future analyses will evaluate this relationship overtime and by treatment arm in the entire sample (n=1200) with adjustment for time since treatment completion.
Keywords: Physical activity, neuropathy, symptoms