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Which diabetes medicines cause weight loss or weight gain? The direction varies by drug class—and weight is only one job on the list. GLP-1 receptor agonists and dual GIP/GLP-1 medicines generally produce
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12 The substitution of GLP-1 Thr 13 or GIP Ile 7 with Ala obviously decreased their receptor-activating activities 25,26 and the substitution of GIP Ile 7 with Thr decreased its cAMP activity (pEC 50 : 9.76→9.58;Emax: 9.91→8.90)
