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GIP (secreted by enteroendocrine K cells, which are predominantly located in the duodenum) and GLP-1 (secreted by enteroendocrine L cells, which are located in the distal gut) are rapidly degraded by the ubiquitous enzyme dipeptidyl peptidase-4 (DPP-4) [1,2,74]
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They reinforce the value of individualized care, prioritize cardiovascular and renal outcomes, and highlight the expanding role of innovative therapies and technologies
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