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IVW combines SNP-specific estimates calculated using Wald ratios, assuming no directional pleiotropy of each SNP ( 2.4.2 Mediation analysis A two-step MR analysis (product of coefficients method) was applied to assess mediation ( Supplementary Figure 1

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More serious but rare adverse effects include pancreatitis, gallbladder disease, hypoglycemia (when used with insulin or sulfonylureas), acute kidney injury (particularly with dehydration), and hypersensitivity reactions including anaphylaxis