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1 These are chemically distinct from the active ingredient found in FDA-approved Ozempic and Wegovy

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PKA RIα biomolecular condensates have also been shown to play a key role in the regulation of GLP-1R signaling in pancreatic β cells, with their disruption leading to changes in β cell Ca 2+ and cAMP oscillation frequencies, insulin secretion, and CREB-mediated gene expression downstream of receptor activation (45)