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Serious side effects of Trulicity that have been reported include: low blood sugar level, which may cause headache problems with kidney function severe problems with digestion, such as extreme vomiting or diarrhea that doesn’t go away acute (short-term) gallbladder disease, including cholecystitis (inflammation in the gallbladder) and gallstones pancreatitis (swelling in the pancreas) boxed warning: risk of thyroid cancer For more information about side effects related to boxed warnings, see the “Precautions” section