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Louisiana Patients Could Lose Access to GLP-1 Weight-Loss Drugs as Coverage Vanishes Highlights Louisiana state employees are already prohibited from using GLP-1s for weight loss despite $200 million annual spending on diabetes coverage Over 41 million Americans lost commercial insurance coverage for Wegovy in 2026, with major insurers eliminating coverage nationwide Four states, including California and Pennsylvania, eliminated Medicaid coverage for obesity treatment between October 2025 and January 2026 Louisiana Medicaid provides limited coverage for one non-GLP-1 weight-loss drug but restrictions remain tight Patients face monthly costs ranging from $936 to $1,349 without insurance coverage BATON ROUGE, La

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GLP-1 is an incretin hormone that regulates blood glucose by stimulating insulin secretion and suppressing glucagon in a glucose-dependent manner GLP-1 secretion is triggered by nutrients (carbohydrates, fats, proteins) and dietary fibre, not by plain water consumption Water promotes satiety through gastric distension rather than hormonal mechanisms involving GLP-1 pathways Evidence-based approaches to support GLP-1 include increasing dietary fibre, consuming adequate protein, and choosing lower glycaemic index foods GLP-1 receptor agonists are NICE-approved medications for type 2 diabetes when other treatments have not achieved glycaemic targets Table of Contents Understanding GLP-1 and Its Role in Blood Sugar Control Glucagon-like peptide-1 (GLP-1) is an incretin hormone produced primarily by specialised L-cells in the distal small intestine and colon