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Is Sitagliptin a GLP-1? Key Differences Explained | PlexusDx

The Phase 2 clinical trial of CagriSema which combined cagrilintide and semaglutide led to 15.6% weight reduction in T2DM patients while achieving superior glycemic control and better outcomes than each drug alone [53,54]

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Importantly, while weight loss represents a major contributor to the clinical benefits of GLP-1RAs, accumulating evidence indicates that these agents also exert non-weight-dependent effects