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As such, exenatide was the first GLP‐1 receptor ligand drug approved for type 2 diabetes in 2005 as a twice‐daily preparation (Nielsen et al., 2004) and was swiftly followed by approval of once‐daily liraglutide (Drucker et al., 2010)

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There’s also some interesting preclinical research on diabetic rats suggesting berberine may slightly nudge up GLP?1 levels, which is the hormone targeted by some popular diabetes medications