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This often leads to: Sustained inhibition even after drug levels drop Lower dosing frequency Reduced risk of resistance in certain settings 2️⃣ High selectivity through modern design “Covalent” does not mean “non-specific.” Advances in CADD/AIDD, reactivity tuning, and pocket analysis allow researchers to precisely position an electrophilic warhead near a nucleophilic residue (often Cys or Ser)