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Particularly, the 5-HT2C receptor (5-HT2CR) and 5-HT1B receptors (5-HT1BRs) are widely expressed in the central nervous system (CNS), mediating the anorexigenic activity of endogenous melanocortin receptor agonists and antagonists at the melanocortin 4 receptor (MC4R) (Lam et al., In the peripheral feed-regulating peptide, ghrelin act conversely with leptin
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