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Hypoglycemia incidence rates were comparable among Tresiba ® and basal insulin comparators 1 Percentage of patients who experienced at least 1 episode of severe or Novo Nordisk–defined hypoglycemia a,b Incidence rates in all T1D adult trials (range): 10.4% to 12.7% for severe hypoglycemia a and 93.0% to 99.4% for Novo Nordisk–defined hypoglycemia b (basal-bolus regimen) a Severe hypoglycemia: an event requiring assistance of another person to actively administer carbohydrate, glucagon, or other resuscitative actions

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1 Introduction Erectile dysfunction (ED), defined as the inability to achieve and maintain an erection sufficient for sexual intercourse, is estimated to occur in 20% of men over the age of 40 and the incidence increases with age ( A recent retrospective cohort study suggested that GLP-1RAs might have induced positive vasculature effects, thereby improving erectile function in patients with T2D ( Mendelian randomization (MR) can generate more reliable evidence with less confounding and reverse causation by using genetic variants related to the exposure or drug target for causal inference and prediction of potential adverse outcomes for a specific drug target ( 2 Methods 2.1 Study design The drug target MR analysis was employed to investigate whether GLP-1RAs causally link to the risk of ED ( Figure 1 )