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A Review in Nature Reviews Endocrinology discusses why patients discontinue GLP-1 receptor agonists and tirzepatide, the metabolic and cardiovascular effects of this discontinuation, and the need for additional research on how to
Several underexplored peptide systems discussed in this review—such as osteocalcin, irisin, and METRNL—exhibit strong phenotypes in rodents but variable or context-dependent signals in humans
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