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This glucose-dependent insulinotropic mechanism explains the low incidence of hypoglycaemic events associated with GLP-1RAs therapy, both when used alone and in dual or triple therapy with metformin, pioglitazone or basal insulin
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Long acting amylin receptor agonist, AZD6234, shows advantages over GLP-1 receptor agonist activation for leptin re-sensitization in a diet-induced obese (DIO) rat model
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