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Tirzepatide has shown an ability to mobilize “stubborn fat” stores, likely through: Enhanced lipolysis Regulation of adipokines Mitochondrial activation and metabolic reprogramming of fat tissue Furthermore, the drug’s proven benefits in conditions like heart failure with preserved ejection fraction (HFpEF) and metabolic-associated steatohepatitis (MASH)-both of which involve fat accumulation and fibrosis-bolster its case as a lipedema treatment
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![GLP-1 Weight-Loss Medication Glucagon-like peptide-1 (GLP-1) receptor agonists (semaglutide [Wegovy, Ozempic, Rybelsus]) and dual incretin agonists (tirzepatide [Zepbound, Mounjaro]) are popular treatments for obesity. The authors discuss the kind of](https://lookaside.fbsbx.com/lookaside/crawler/media/?media_id=1050961973852737)
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