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As previously mentioned, because DPP-4 inhibitors can increase the risk of hypoglycemia when added to insulin or a sulfonylurea, a dose decrease of sulfonylurea and/or insulin should be considered prior to initiation of a DPP-4 inhibitor
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Additionally, if you're experiencing symptoms such as persistent abdominal pain, blood in your stools, excessive weight loss, or any symptoms that significantly interfere with your day-to-day activities, it's important to speak with your prescribing physician, as you may need to temporarily reduce your GLP-1 dose and be screened for more serious causes of your symptoms, such as IBD or colorectal cancer
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