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Whilst it does not directly damage or 'eat away' at muscle tissue, weight loss achieved through this medication—like any weight loss method—typically includes some reduction in lean muscle mass alongside fat loss

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In a series of clinical trials (SURPASS 1-5) individuals with type 2 diabetes have shown reduction in both HbA1c (1.2 to 2.6%) and body weight (5.4–11.7 kg) (Nauck and D'Alessio 2022)