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In rodent studies, GLP-1RAs reduced oxidative stress and autophagy, smooth muscle dysfunction, enhanced nitric oxide-mediated diastole, protected endothelial cell function in the corpus cavernosum and reduced proinflammatory cytokine expression in the testes ( Diabetes, obesity and ED are closely linked ( The potential significance of our study is that it provides some evidence of the safety of GLP-1RAs on male sexual function, and suggests that GLP-1RAs might be a potential preventive drug for ED, especially in people with diabetes or obesity
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