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At higher doses, methylene blue could trigger a hemoglobin reduction or possibly hemolysis in someone with G6PD deficiency.[ref] Methylene blue is also an MAO-A inhibitor, which could interact with medications (MAOIs, SSRIs) or even alter mood in someone with MAO-A variants.[ref] If you are taking SSRIs, methylene blue at higher doses increases the risk of serotonin syndrome, which can be life-threatening.[ref] Anyone pregnant or nursing should not use methylene blue.[ref] In the Genotype Report section below, I’ll include the more common G6PD mutations as well as MAO-A variants to consider
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