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My doctor told me that it was due to abnormal functioning of immune cells, such as T and B lymphocytes, which caused autoimmune disease and led to goiter
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The relative rate reduction observed for GLP-1 receptor agonists versus DPP-4 inhibitors (21% reduction) was similar to the reduction observed for SGLT-2 inhibitors versus DPP-4 inhibitors (25% relative reduction in hazard)