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But this study introduces genuine doubt about whether the theoretical synergy between phentermine and incretin-based drugs translates into real-world clinical benefit

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Key points: We need to eat in a calorie deficit to lose weight If our baseline diet is rich in ultra-processed foods and we continue to eat this way on semaglutide, we may still consume more calories than we need to lose weight It’s essential to eat a diet based on whole foods to support sustainable weight loss 2) You’re in a weight-loss plateau Suppose we’ve lost some weight on semaglutide, but then we hit a plateau, and we can’t budge the scales any more