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Furthermore, semaglutide prevents MASLD/MASH-driven HCC progression in metabolic preclinical models, partly by correcting adipokine imbalances (low adiponectin, high leptin) associated with insulin resistance, which removes a key chronic inflammatory and pro-oncogenic signal linked to the disease (Kojima et al., 2020)
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Personalized Alternatives: Finding Your Long-Term Solution Rather than an all-or-nothing approach, many patients benefit from transitioning to a lower-dose maintenance protocol