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For example, MC4R knockout mice exhibit significantly increased hypothalamic expression of neuropeptide Y (NPY) and agouti-related protein (AgRP), while pro-opiomelanocortin (POMC) expression is decreased compared with wild-type controls [56]
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Emerging research also suggests that sex hormones may interact with GLP‑1 pathways in ways that influence appetite, metabolic health, and brain signaling
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