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Mediational analysis indicated that weight loss partially mediated the causal effects of GLP-1 RAs on depression and emotional lability, accounting for 18.28% (95% CI: 9.46–27.10%, P = 0.038) and 7.65% (95% CI: 5.66–9.64%, P 0.01 to proxy for GLP-1 RAs exposure

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Many people notice significantly reduced alcohol tolerance on these medications, and even moderate drinking can produce disproportionate fatigue