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Other Extra-Pancreatic Sites of GLP-1R Expression The vast range of extra-pancreatic effects exerted by GLP-1 RAs (Figure 2) may be due to the combination of multiple activated intracellular signalling pathways and the breadth of GLP-1R expression across the human body

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But the reason it does not is genuinely interesting, and it comes down to bioavailability — the fraction of a swallowed dose that actually reaches your bloodstream