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The study further noted that metformin improves weight loss by enhancing insulin resistance, promoting appetite suppression through increased GLP-1 and peptide YY (tyrosine-tyrosine) secretion, increasing hypothalamic leptin sensitivity, altering gut microbiome, and inducing growth-differentiating factor 15—which collectively reduce food intake and improve metabolic function
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doi: 10.1016/j.bbrc.2017.11.016
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