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ADVANTAGES & DISADVANTAGES OF TREATMENT OPTIONS CVD: Cardiovascular Death Management of Type 2 Diabetes American Diabetes Assn 2020 Update Based upon recent research findings, the American Diabetes Asson & Europiean Asson for the Study of Diabetes recently updated their consensus treatment recommendations (Buse et al, 2019) for the following subsets of patients with diabetes: High risk diabetic patients GLP-1 agonists & SGLT2 inhibitors to reduce CV & renal risk in “high risk” patients, without regard to patient HbA1c levels (baseline or target) High risk for atherosclerotic CV disease GLP-1 agonists GLP-1 agonists produce the greatest benefit against CV events Systolic heart failure (HFrEF) & chronic kidney disease (CKD) SGLT2 inhibitors SGLT2 inhibitors have the greatest benefit to prevent progression of CKD, reduce hospitalization for HF, and reduce CV events & CV death Patients with foot ulcers SGLT2 inhibitors a recommended treatment, after consideration of risk vs benefits 2021 ADA Treatment Guidelines Figure 10
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For GLP-1R and GIPR, both tirzepatide and MAR709 showed strikingly decreased receptor internalization compared to mono agonist
