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Since the original papers were published, the management of type 1 diabetes has advanced: continuous and flash glucose monitoring give us a much better idea of glucose variability within an individual, and we now regularly measure C-peptide levels and are starting to get a clearer view of residual beta-cell function in people with type 1 diabetes

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Importantly, not all variants confer increased risk: loss of function variants in HSD17B13, a lipid droplet-associated protein in hepatocytes, have been consistently associated with reduced hepatic inflammation and a lower risk of fibrosis and advanced liver disease [16]