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Animal models have also identified interaction pathways between the brain and adipose tissue, as well as between the brain and the microbiota, indicating that peripheral events strongly influence central nervous system activity and behavior ( The complex etiopathogenesis of T2DM has been explored in detail and includes insulin resistance (in the liver, muscles, and adipose tissue), impaired insulin secretion, Ξ²-cell dysfunction, immune dysregulation and meta-inflammation, hyperglucagonemia, disrupted gut microbiota, increased gastric glucose absorption, renal adaptation with enhanced glucose reabsorption and gluconeogenesis, decreased dopamine, and heightened sympathetic tone in the brain (McLean et al., 2021)
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We dug into the latest research and spoke with endocrinologists, obesity specialists and psychologists to understand what really happens when you stop taking one of these medications β and how to make the transition as successfully as possible
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