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Common side effects of semaglutide include: Nausea Vomiting Diarrhea Stomach pain Decreased appetite Indigestion Belching Constipation Other side effects that are reported less commonly include: Headache Dizziness Fatigue Hair loss Muscle pain Injection site reactions (redness or irritation) Serious (and rare) side effects of semaglutide include: Low blood sugar (hypoglycemia) Pancreatitis (inflammation of the pancreas) Gallbladder disease Changes in vision (diabetic retinopathy) Allergic reactions Kidney problems Semaglutide may increase the risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC)