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GLP-1 Weight Loss Drugs: Miracle, Mess, or Something in Between?

Stopping the medication often leads to weight regain for patients if permanent lifestyle changes were not made

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Accordingly, postbiotics should be interpreted as adjunctive nutritional strategies rather than pharmacological alternatives to GLP-1 receptor agonists, with the most plausible utility during consolidation and maintenance phases aimed at improving metabolic context and supporting long-term weight-loss sustainability ( Figure 1 Importantly, accumulating preclinical evidence indicates that certain postbiotic preparations can attenuate weight gain, reduce adiposity, and activate thermogenic pathways, including brown adipose tissue signaling, particularly in high-fat diet–fed rodent models

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