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At day 6 after the first infusion, the semaglutide-treated and GLP-1โMK-801-treated mice were crossed-over in terms of treatment and administered with another single infusion of either GLP-1โMK-801 (0.22 nmol, 2 ยตl) and semaglutide (0.22 nmol, 2 ยตl), respectively, while vehicle-treated mice received vehicle treatment once again
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In this study, we demonstrate that GLP-1 is able to mediate the insulinotropic effect of T3, thereby endowing the T3 with the ability to modulate glucose homeostasis
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