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Pack size:12 cans
Retatrutide Structure and Chemistry Retatrutide builds on the engineering principles refined in semaglutide and tirzepatide: Glucagon-based peptide backbone — retatrutide is derived from glucagon, with modifications to give it activity at all three target receptors Strategic amino acid substitutions — multiple substitutions tune the receptor activity balance across GLP-1R, GIPR, and glucagon receptor Fatty acid chain attached — for albumin binding and extended half-life (similar strategy to semaglutide and tirzepatide) Aminoisobutyric acid substitutions — protect against DPP-4 enzymatic degradation The triple-agonist design is technically demanding because each receptor has different binding requirements
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