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It is important to note that receptor desensitization, feedback suppression, and compensatory signaling are by no means unique to peptides—these phenomena are well documented for small-molecule drugs, including beta-blockers, opioids, and statins

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Abstract Renal involvement in systemic lupus erythematosus (SLE) represents one of the most frequent organ manifestations, often leading to end-stage kidney disease (ESKD)