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Inhibiting DPP-4 enzyme activity The enzyme dipeptidyl peptidase-4 (DPP-4) rapidly breaks down natural GLP-1, giving it a half-life of only 1-2 minutes
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Because GLP-1 receptors exist in the brain and these drugs damp inflammation, researchers had real reason to think they might slow neurodegenerative disease, and encouraging early studies fueled the excitement
