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Accordingly, this section summarizes GLP-1RA and DPP-4is related mechanisms, with a focus on DPP-4is/GLP-1-mediated central effects ( Figure 2 ), to support the biological plausibility of the proposed “DPP-4is-gut microbiota-SCFAs-GLP-1 axis.” Figure 2 4.1 Enhancement of inhibitory synaptic transmission γ -aminobutyric acid (GABA)-mediated inhibitory synaptic transmission plays a critical role in regulating the excitability of neural circuits and controlling epileptic seizures
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[DOI] [PubMed] [Google Scholar] 32.Wang C., Li Q., Wang W., Guo L., Guo C., Sun Y., Zhang J